Analysis of the reactions used for the preparation of drug candidate molecules
John CareyGlaxoSmithKline Pharmaceuticals, Old Powder Mills, Tonbridge, UK. [email protected]David LaffanAstraZeneca PR&D, Silk Road Business Park, Macclesfield, Cheshire, UKColin ThomsonAstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leics, UKMike T. WilliamsPfizer Global R&D, Sandwich, Kent, UK
2006en
ABI
Abstract
The purpose of this perspective is to indicate the range of chemistries used in the manufacture of drug candidate molecules and to highlight certain gaps in current technologies. To do this a survey was carried out of chemical syntheses within the Process Chemistry R&D departments of GlaxoSmithKline, AstraZeneca and Pfizer.
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