New alkaloids from <i>Aconitum taipaicum</i> and their cytotoxic activities
Zengjun GuoFaculty of Pharmacy, Medical College of Xi'an Jiaotong University, Xi'an 710061, P.R. ChinaYing XuFaculty of Pharmacy, Medical College of Xi'an Jiaotong University, Xi'an 710061, P.R. ChinaHui ZhangFaculty of Pharmacy, Medical College of Xi'an Jiaotong University, Xi'an 710061, P.R. ChinaMengyi LiFaculty of Pharmacy, Medical College of Xi'an Jiaotong University, Xi'an 710061, P.R. ChinaKe XiFaculty of Pharmacy, Medical College of Xi'an Jiaotong University, Xi'an 710061, P.R. China
2013en
ABI
Abstract
Three new aconitine-type C19-diterpenoid alkaloids, taipeinines A-C (1-3), were isolated from the roots of Aconitum taipaicum. The chemical structures of these three compounds were established as (1α,6α,8α,14α,16α)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (1), (1α,6α,8α,14α,16β)-20-ethyl-8,14-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane (2) and (1α,6α,8α,14α,16α)-20-ethyl-1,8,14-trihydroxy-6,16-dimethoxy-4-(methoxymethyl)-aconitane (3), respectively, on the basis of spectroscopic analyses, mainly MS, 1D and 2D NMR. The cytotoxic activities of these compounds were also assayed, and the results were quite impressive.
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