Article

Certain Norditerpenoid Alkaloids and Their Cardiovascular Action

Haridutt K. DesaiInstitute for Natural Products Research and Department of Chemistry, The University of Georgia, Athens, Georgia 30602-2556, and Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912Bradley P. HartInstitute for Natural Products Research and Department of Chemistry, The University of Georgia, Athens, Georgia 30602-2556, and Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912Robert W. CaldwellInstitute for Natural Products Research and Department of Chemistry, The University of Georgia, Athens, Georgia 30602-2556, and Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912Jianzhong-HuangInstitute for Natural Products Research and Department of Chemistry, The University of Georgia, Athens, Georgia 30602-2556, and Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912S. William PelletierInstitute for Natural Products Research and Department of Chemistry, The University of Georgia, Athens, Georgia 30602-2556, and Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia 30912

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Abstract

Thirteen new derivatives of norditerpenoid alkaloids, namely, 8-deacetyl-8-p-aminobenzoyldelphinine (1), 8-deacetyl-8-anthranoyldelphinine (2), 8-deacetyl-8-(4-hydroxy-3-methoxycinnamoyl)delphinine (3), 16-demethoxy-15,16-didehydro-8-p-anisoyl-14-benzoyldelpho nine (4), 6-acetylheteratisine N-oxide (6), 3,8-diacetylfalconerine (7), 8-stearoylfalconerine (8), 8-linolenylfalconerine (9), 13-acetylpyrodelphinine (11), 13-acetyldelphinine N-oxide (13), N-deacetyl-8,9-diacetyllappaconitine (14), 8, 9-(methylenedioxy)lappaconine (15), and 16-epipyroaconitine N-oxide (17), were prepared, and their structures were established by analysis of spectroscopic data (1D and 2D NMR, HRFABMS). The preliminary in vivo cardiovascular action (hypotensive, bradycardic, and ventricular arrhythmias) of these new compounds was tested in male Sprague-Dawley rats. The results are reported herein.

Identifiers

DOI: 10.1021/np970499j

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