Synthesis and antimicrobial activity of new 1,2,4-triazole and 1,3,4-thiadiazole derivatives
Tíjen ÖnkolDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, TurkeyDeniz S. DoğruerDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, TurkeyLeyla UzunDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, TurkeySelcen AdakDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, TurkeySíbel A. ÖzkanDepartment of Microbiology, Faculty of Pharmacy, Gazi University, Ankara, TurkeyMustafa ŞahinDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey
2008en
ABI
Abstract
In this study, new 3-[(1(2H)-phthalazinone-2-yl(methyl/ethyl]-4-aryl-1,2,4-triazole-5-thione and 2-[[1(2H)-phthalazinone-2-yl]methyl/ethyl]-5-arylamino-1,3,4-thiadiazole derivatives were synthesized. Antimicrobial properties of the title compounds were investigated against two Gram (+) bacteria (S. aureus, B. subtilis), two Gram ( - ) bacteria (P. aeruginosa, E. coli) and two yeast-like fungi (C. albicans and C. parapsilosis) using the broth microdilution method. Generally the compounds were found to be active against B. subtilis and the fungi. Derivatives carrying a 1,3,4-thiadiazole ring generally showed higher antimicrobial activity against B. subtilis and the fungi when compared to other synthesized compounds.
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