Article

Thiocarbamates from<i> Moringa oleifera</i> Seeds Bioactive against Virulent and Multidrug-Resistant<i> Vibrio</i> Species

Renata Albuquerque CostaFederal University of Ceará, Fortaleza, CE, BrazilOscarina Viana de SousaSea Sciences Institute, Federal University of Ceará, Fortaleza, CE, BrazilErnesto HoferOswaldo Cruz Institute, Rio de Janeiro, RJ, BrazilJair MafezoliDepartment of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, CE, BrazilFrancisco Geraldo BarbosaDepartment of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, CE, BrazilRegine Helena Silva dos Fernandes VieiraSea Sciences Institute, Federal University of Ceará, Fortaleza, CE, Brazil

2017en

ABI

Abstract

Prospect of antibacterial agents may provide an alternative therapy for diseases caused by multidrug-resistant bacteria. This study aimed to evaluate the in vitro bioactivity of Moringa oleifera seed extracts against 100 vibrios isolated from the marine shrimp Litopenaeus vannamei . Ethanol extracts at low (MOS-E) and hot (MOS-ES) temperature are shown to be bioactive against 92% and 90% of the strains, respectively. The most efficient Minimum Inhibitory Concentration (MIC) levels of MOS-E and MOS-ES against a high percentage of strains were 32 µ g mL −1 . Bioguided screening of bioactive compounds showed that the ethyl acetate fraction from both extracts was the only one that showed antibacterial activity. Vibriocidal substances, niazirine and niazimicine, were isolated from the aforementioned fraction through chromatographic fractionation.

Identifiers

DOI: 10.1155/2017/7963747

Citations and references

Cited by 20 references

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