Synthesis, antimicrobial and antioxidant activity of bis sulfonamide/carbamate derivatives of bis‐(4‐aminophenyl) methane
Vadabingi NagalakshmammaDepartment of Chemistry Sri Venkateswara Arts College (TTD's) Tirupati Andhra Pradesh IndiaMavallur VaralakshmiCentre for Applied Sciences Sree Vidyanikethan Engineering College Tirupati Andhra Pradesh IndiaKollu UmapriyaDepartment of Chemistry Sri Venkateswara University Tirupati Andhra Pradesh IndiaM. VenkataswamyDepartment of Biochemistry Sri Venkateswara University Tirupati Andhra Pradesh IndiaChintha VenkataramaiahDepartment of Zoology Sri Venkateswara University Tirupati Andhra Pradesh IndiaKedam Thyaga RajuDepartment of Biochemistry Sri Venkateswara University Tirupati Andhra Pradesh IndiaPonne Venkata ChalapathiDepartment of Chemistry Sri Venkateswara Arts College (TTD's) Tirupati Andhra Pradesh IndiaNagaraju ChamarthiDepartment of Chemistry Sri Venkateswara University Tirupati Andhra Pradesh India
2020en
ABI
Abstract
Abstract A series of new bis sulfonamide/carbamate derivatives of bis‐(4‐aminophenyl)methane 3 ( a–d )/ 5 ( a–f ) were synthesized from bis‐(4‐aminophenyl)methane ( 1 ) using various pharmacologically active sulfonyl chlorides 2 ( a–d ) and carbonochloridates 4 ( a–f ) in high yields. The structures of all the newly synthesized compounds were characterized by the Infrared spectroscopy, NMR ( 1 H and 13 C), mass, and elemental analyses. Further, all the synthesized compounds were tested for the antioxidant activity by using 2, 2‐diphenyl‐1‐picrylhydrazyl, NO, and H 2 O 2 scavenging methods and antimicrobial activity. Most of the compounds exhibited good antioxidant and antimicrobial activities.
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