Mn‐Catalyzed Electrochemical Synthesis of Quinazolinones from Primary Alcohols/Benzyl Ethers and <i>o</i>‐Aminobenzamides
Dian‐Zhao LinKey Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510640 P.R. CHINAYinlong LaiKey Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510640 P.R. CHINAJing‐Mei HuangKey Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510640 P.R. CHINA
2018en
ABI
Abstract
Abstract An efficient approach for the synthesis of quinazolinones from o ‐aminobenzamides and alcohols by the combination of electrochemistry and redox‐metal catalysis has been developed. Taking manganese(II) sulfate as a redox catalyst, this transformation proceeded smoothly under ambient conditions in an undivided cell to afford quinazolinones in moderate to excellent yields with a wide substrate scope. Benzyl ethers were also suitable participants in the cascade cyclization sequence.
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