Article

Secondary Metabolites from <i>Solanum rostratum</i> and Their Antifeedant Defense Mechanisms against <i>Helicoverpa armigera</i>

Ce LiuLiaoning Key Laboratory for Biological Invasions and Global Changes, College of Biological Science and Technology, Shenyang Agricultural University, Shenyang, Liaoning 110866, People’s Republic of ChinaJinlong TianCollege of Food Science, Shenyang Agricultural University, Shenyang, Liaoning 110866, People’s Republic of ChinaTong AnLiaoning Key Laboratory for Biological Invasions and Global Changes, College of Biological Science and Technology, Shenyang Agricultural University, Shenyang, Liaoning 110866, People’s Republic of ChinaFeinan LyuLiaoning Key Laboratory for Biological Invasions and Global Changes, College of Biological Science and Technology, Shenyang Agricultural University, Shenyang, Liaoning 110866, People’s Republic of ChinaPengfei JiaLiaoning Key Laboratory for Biological Invasions and Global Changes, College of Biological Science and Technology, Shenyang Agricultural University, Shenyang, Liaoning 110866, People’s Republic of ChinaMingjia ZhouLiaoning Key Laboratory for Biological Invasions and Global Changes, College of Biological Science and Technology, Shenyang Agricultural University, Shenyang, Liaoning 110866, People’s Republic of ChinaZhixiang LiuLiaoning Key Laboratory for Biological Invasions and Global Changes, College of Biological Science and Technology, Shenyang Agricultural University, Shenyang, Liaoning 110866, People’s Republic of ChinaYu‐Long FengLiaoning Key Laboratory for Biological Invasions and Global Changes, College of Biological Science and Technology, Shenyang Agricultural University, Shenyang, Liaoning 110866, People’s Republic of China

2019en

ABI

Abstract

Solanum rostratum is a worldwide malignant invasive weed, causing serious harm to the ecological environment and biodiversity. Strong chemical defense against herbivorous insects is supposed to be one of the successful invasive mechanisms of this exotic plant. However, the real defense components and their action mechanisms and distributions are still unknown. To address these problems, we bioassay-guided isolated compounds from the aerial part of S. rostratum and determined their structures using high-resolution electrospray ionization mass spectrometry, nuclear magnetic resonance, and electronic circular dichroism calculation. One new and seven known compounds were identified, and all of the isolates exhibited different levels of antifeedant activities, especially compounds 1 and 4. Consistently, compounds 1 and 4 displayed potent inhibitory effects on antifeedant-related enzymes (AchE and CarE). The action mechanisms of active compounds 1 and 4 were revealed by molecular docking and molecular dynamic simulation studies. Furthermore, the distributions of the active compounds in leaves, stems, and flowers were also analyzed by liquid chromatography–mass spectrometry.

Identifiers

DOI: 10.1021/acs.jafc.9b06768

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Cited by 30 references

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