Nanobody-engineered bispecific IL-18 mimetics drive antitumor immunity by engaging CD8+ T cell and evading IL-18BP in preclinical models
Yanyang NanDepartment of Biological Medicines, School of Pharmaceutical Sciences, Shanghai Engineering Research Center of Immunotherapeutics, Fudan University, Shanghai 201203, ChinaMin ZhuQian WangDepartment of Biological Medicines, School of Pharmaceutical Sciences, Shanghai Engineering Research Center of Immunotherapeutics, Fudan University, Shanghai 201203, ChinaXiaoxue DuDepartment of Biological Medicines, School of Pharmaceutical Sciences, Shanghai Engineering Research Center of Immunotherapeutics, Fudan University, Shanghai 201203, ChinaCaili XuDepartment of Biological Medicines, School of Pharmaceutical Sciences, Shanghai Engineering Research Center of Immunotherapeutics, Fudan University, Shanghai 201203, ChinaYuping HuangYujie LiuDepartment of Biological Medicines, School of Pharmaceutical Sciences, Shanghai Engineering Research Center of Immunotherapeutics, Fudan University, Shanghai 201203, ChinaShaoyuan ZhouDepartment of Biological Medicines, School of Pharmaceutical Sciences, Shanghai Engineering Research Center of Immunotherapeutics, Fudan University, Shanghai 201203, ChinaYuluoyan QiuXiao ChuDepartment of Thoracic Surgery, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China. Electronic address: [email protected]Dianwen JuDepartment of Biological Medicines, School of Pharmaceutical Sciences, Shanghai Engineering Research Center of Immunotherapeutics, Fudan University, Shanghai 201203, China. Electronic address: [email protected]Yakun WanShanghai Novamab Biopharmaceuticals Co., Ltd., Shanghai 201318, China. Electronic address: [email protected]Xuyao ZhangDepartment of Biological Medicines, School of Pharmaceutical Sciences, Shanghai Engineering Research Center of Immunotherapeutics, Fudan University, Shanghai 201203, China; Quzhou Fudan Institute, Quzhou 324002, China. Electronic address: [email protected]
2025en
ABI
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