Article

Diabetes is a risk factor for the progression and prognosis of <scp>COVID</scp>‐19

Weina GuoDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaMingyue LiDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaYalan DongDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaHaifeng ZhouDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaZili ZhangDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaChunxia TianDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaRenjie QinDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaHaijun WangDepartment of Neurosurgery, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaYin ShenDepartment of Neurosurgery, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaKeye DuDepartment of Neurosurgery, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaLei ZhaoDepartment of Infectious Disease, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaHeng FanDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaShanshan LuoInstitute of Hematology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDesheng HuDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China

2020en

ABI

Abstract

BACKGOUND: To figure out whether diabetes is a risk factor influencing the progression and prognosis of 2019 novel coronavirus disease (COVID-19). METHODS: A total of 174 consecutive patients confirmed with COVID-19 were studied. Demographic data, medical history, symptoms and signs, laboratory findings, chest computed tomography (CT) as well the treatment measures were collected and analysed. RESULTS: We found that COVID-19 patients without other comorbidities but with diabetes (n = 24) were at higher risk of severe pneumonia, release of tissue injury-related enzymes, excessive uncontrolled inflammation responses and hypercoagulable state associated with dysregulation of glucose metabolism. Furthermore, serum levels of inflammation-related biomarkers such as IL-6, C-reactive protein, serum ferritin and coagulation index, D-dimer, were significantly higher (P < .01) in diabetic patients compared with those without, suggesting that patients with diabetes are more susceptible to an inflammatory storm eventually leading to rapid deterioration of COVID-19. CONCLUSIONS: Our data support the notion that diabetes should be considered as a risk factor for a rapid progression and bad prognosis of COVID-19. More intensive attention should be paid to patients with diabetes, in case of rapid deterioration.

Identifiers

DOI: 10.1002/dmrr.3319

Citations and references

Cited by 20 references

Metrics — AkademScholar