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Abstract
Ganoderma is a miracle edible mushroom with unique composition and miraculous health benefits.The investigation aimed to elucidate interactions for the active compounds of Ganoderma lucidum namely Ganoderol A, Ganoderol B, Ganoderal A and Ganoderic Acid Y with Lanosterol 14 alpha demethylase enzyme using molecular docking software Arguslab.The effect of ganomycin1 and 2 as an inhibitor against HIV 1 protease and Tyrosinase were carried out using molecular docking software DOCK 6.3.The in-silico docking analysis of Ganoderma lucidum triterpenes was found to be effective as inhibitors of Lanosterol 14 alpha demethylase.The grid score and best scored conformations of Ganomycin 1 and 2 suggest that both have a significant inhibitory effect on these enzymes, comparable to the known inhibitors.The docking results showed significant inhibitory action of these compounds indicating the possibility that they can be used as potent drugs in the future.Thus these natural compounds have diverse structural and biological properties which can serve them to be utilized as a valuable lead molecule for the treatment of various diseases. INTRODUCTION:Ganoderma is a genus of polypore mushroom.It is a valuable herb due to its biological activity such as anti-tumor, antioxidant, antidiabetic, anti-inflammatory, antimicrobial, immune-modulatory and hypo-lipidemic effect 1 .The pharmacological active compounds in Ganoderma lucidum are the polysaccharides, triterpenoids, alkaloids, organic germanium, ergo sterols include farnesyl hydroquinones named ganomycin 1 and ganomycin 2 2, 3 .High cholesterol levels are deemed as a risk factor in heart disease.In cholesterol synthesis, HMG CoA reductase is the rate limiting enzyme and is inhibited by various drugs.