Lycaconitine Revisited: Partial Synthesis and Neuronal Nicotinic Acetylcholine Receptor Affinities
John M. JacynoCollege of Pharmacy, Ohio Northern University, Ada, Ohio 45810John S. HarwoodChemistry Department, M/C-111, University of Illinois at Chicago, Chicago, Illinois 60607Nan‐Horng LinNeuroscience Research, Pharmaceutical Discovery, Abbott Laboratories, Abbott Park, Illinois 60064Jeffrey E. CampbellNeuroscience Research, Pharmaceutical Discovery, Abbott Laboratories, Abbott Park, Illinois 60064James P. SullivanNeuroscience Research, Pharmaceutical Discovery, Abbott Laboratories, Abbott Park, Illinois 60064Mark W. HolladayNeuroscience Research, Pharmaceutical Discovery, Abbott Laboratories, Abbott Park, Illinois 60064
1996en
ABI
Abstract
The norditerpenoid alkaloid lycaconitine (2) was synthesized from lycoctonine (3) and its affinity determined for two neuronal nicotinic acetylcholine receptor subtypes. The structure of 2 was confirmed by a combination of spectroscopic methods.
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