Stereoselective Electro‐2‐deoxyglycosylation from Glycals
Miao LiuState Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Xue Yuan Road No. 38 Beijing 100191 ChinaKaimeng LiuState Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Xue Yuan Road No. 38 Beijing 100191 ChinaDe‐Cai XiongShandong Key Laboratory of Carbohydrate Chemistry and Glycobiology Shandong University 27 Shanda Nanlu Jinan Shandong 250100 ChinaHanyu ZhangState Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Xue Yuan Road No. 38 Beijing 100191 ChinaTian LiState Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Xue Yuan Road No. 38 Beijing 100191 ChinaBohan LiState Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Xue Yuan Road No. 38 Beijing 100191 ChinaXianjin QinState Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Xue Yuan Road No. 38 Beijing 100191 ChinaJinhe BaiState Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Xue Yuan Road No. 38 Beijing 100191 ChinaXin‐Shan YeState Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Xue Yuan Road No. 38 Beijing 100191 China
2020en
ABI
Abstract
We report a novel and highly stereoselective electro-2-deoxyglycosylation from glycals. This method features excellent stereoselectivity, scope, and functional-group tolerance. This process can also be applied to the modification of a wide range of natural products and drugs. Furthermore, a scalable synthesis of glycosylated podophyllotoxin and a one-pot trisaccharide synthesis through iterative electroglycosylations were achieved.
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