Electrophoretic Method for Characterizing Thyroid Function
Sheldon BergerAssistant director, Department of Metabolic and Endocrine Research, Michael Reese Hospital and Medical CenterM. S. GoldsteinDirector, Department of Metabolic and Endocrine Research, Michael Reese Hospital and Medical CenterBoyd E. MetzgerTrainee, National Institute of Arthritis and Metabolic Diseases (training grant 2A–5255), United States Public Health Service
1962en
ABI
Abstract
VIRTUALLY all the thyroxine (T4) in plasma circulates in association with various carrier proteins.1 2 3 4 The electrophoretic identity of these proteins depends upon experimental conditions, however, and herein lay the basis of a controversy that has surrounded efforts to characterize the "physiologic" carrier proteins. An inter-alpha globulin (the thyroxine-binding globulin, or TBG) is generally conceded to be the major thyroxine carrier; the albumin fraction shows a lesser but consistent role in thyroxine transport. The demonstration of a prealbumin carrier by Ingbar5 (thyroxine-binding prealbumin, or TBPA) has generated some discussion3 , 6 , 7 since this fraction shows no affinity for thyroxine when a . . .
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