[Activity of the NO-system in lung after pulmonectomy of various volumes].

Abstract

The study was designed to evaluate the activity of NO-system in lung after resection of various volumes. White male rats, subjected to left or right pulmonectomy, were used. Activity of the NO-system in lung was estimated as a difference in the contents of its metabolites (nitrates NO3(-) and nitrites NO2(-)), peroxynitrite (ONOO(-)), activity of endothelial (eNOS) and induced enzyme (iNOS), in arterial and venous blood for 3, 7, 14 day after pulmonectomy. It was revealed, that with the increase of a resections volume, activity of NO-system was reduced. Difference in parameters of NO-system activity in arterial and venous blood reflects endothelial dysfunctions in lung, and can be used as diagnostic criterion.

Citations and references