MECHANISM OF TEAR FILM DISRUPTION IN DRY EYE SYNDROME
Tolmasov Ruzibek TolmasovichTashkent State Medical University Senior Lecturer PhD of the Department of Human Anatomy and OSTARaxmonova Nasiba Abdusattor qiziTashkent State Medical University Treatment Case No. 2 Faculty studentUsmanova Gulyora Zohidjon qiziTashkent State Medical University Treatment Case No. 2 Faculty student
Zenodo (CERN European Organization for Nuclear Research)repository2026
ABI
Abstract
Dry eye syndrome is a multifactorial ocular surface disease characterized by tear film instability, hyperosmolarity, inflammation, and neurosensory dysfunction. Recent studies, including the DEWS II report developed by TFOS, have revised the classic three-layer model of the tear film, emphasizing that it is a dynamic and interconnected structure. The article analyzes the mechanisms of tear film disruption based on lipid layer deficiency, aqueous component depletion, mucin dysfunction, hyperosmolarity, and the inflammatory cascade.
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