ROLE OF LYSYL OXIDASE IN THE PATHOGENESIS OF INTERSTITIAL LUNG INJURY
Rikhsi Abdukadirovna SabirovaDSc, Professor Tashkent State Medical UniversityD. TursunovPhD, Associate Professor Tashkent State Medical University
Zenodo (CERN European Organization for Nuclear Research)repository2026
ABI
Abstract
This study investigates the activity of lysyl oxidase family enzymes (LOX-1–4) in experimental interstitial pneumonia. All LOX isoforms demonstrated a marked increase—more than 2.7-fold—in serum and lung homogenates compared with intact animals, indicating enhanced fibrotic and tissue-remodeling processes. LOX-3 showed the highest baseline activity. These findings confirm the pivotal role of LOX enzymes in the pathogenesis of interstitial lung injury and support the potential use of LOX-1–4 as biomarkers for assessing fibrosis severity and progression.
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