Heterogeneous Fe single-atom catalysis for C2–H amidation of pyridine/quinoline <i>N</i>-oxides: streamlined synthesis of pharmaceutical scaffolds
Jinhua OuSchool of Material and Chemical Engineering, Hunan Institute of Technology, 421002, Hengyang, ChinaSong YuDepartment of Chemistry, School of Natural Sciences, The University of Manchester, Manchester, M13 9PL, UKDuoduo LiuSchool of Material and Chemical Engineering, Hunan Institute of Technology, 421002, Hengyang, ChinaHan JiangSchool of Material and Chemical Engineering, Hunan Institute of Technology, 421002, Hengyang, ChinaCan LyuSchool of Material and Chemical Engineering, Hunan Institute of Technology, 421002, Hengyang, ChinaKeyi ChenSchool of Material and Chemical Engineering, Hunan Institute of Technology, 421002, Hengyang, ChinaJinghong LiSchool of Material and Chemical Engineering, Hunan Institute of Technology, 421002, Hengyang, ChinaZhuobin YuSchool of Material and Chemical Engineering, Hunan Institute of Technology, 421002, Hengyang, ChinaKaijian LiuSchool of Material and Chemical Engineering, Hunan Institute of Technology, 421002, Hengyang, ChinaJinxuan LiuState Key Laboratory of Fine Chemicals, Leicester International Institute, Liaoning Binhai Laboratory, Dalian University of Technology, 116024, Dalian, P. R. China
2025en
ABI
Abstract
This first heterogeneous catalytic system enables base/additive-free C2–H amidation of N -oxides with 100% atom economy for pharmaceutical synthesis.
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