Synthesis and Bio-evaluation of Nano-hydroxyapatite Trapped by ~(153)Sm (In Chinese)

After nanoHA was synthesized, ~ 153 Sm-EDTMP-nanoHA and ~ 153 Sm-citrate-nanoHA were prepared and proved stable in vitro. ECT images of New Zealand rabbits injected with ~ 153 Sm-EDTMP-nanoHA had better contrast, skeletal figure visible, liver and spleen clear. The images of ~ 153 Sm-citrate-nanoHA showed a similar results but kidney invisible, which meant ~ 153 Sm-citrate-nanoHA was mainly excreted through liver and gall. ~ 153 Sm-EDTMP-nanoHA’s half effective inhibition concentrations to SMMC-7721 and MCF-7 cells were 1.98 g/L and 0.075 g/L respectively and ~ 153 Sm-citrate-nanoHA’s were 1.89 g/L and 0.094 g/L proportionally. ~ 153 Sm-EDTMP-nanoHA and ~ 153 Sm-citrate-nanoHA were worthy of a further research because their half effective inhibition concentrations were much lower than ones of the single nanoHA.

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