Preparation of Domperidone Dispersible Tablets

OBJECTIVE To optimize the preparation craft and the formula of Domperidone Dispersible Tablets.METHODS The adjuvant like disintegrant etc.,the formula and preparation process were optimized by a series of Orthogonal experiments.The dissolution rates of the principal agent in dispersible tablets and conventional tablets were determined and compared.RESULTS and CONCLUSION Optimized formula: Domperidone 10g,starch 25g,lactose 50g,crospolyvinylpyrrolidone 10g,aspartame 1g,magnesium stearate 1g,5%polyvidone in water,to make 1000 tablets.The dissolution rate of the dispersible tablet was faster than conventional tablets.

Перевод пока недоступен