GLC-MS profiling of non-polar extracts from Phlomis bucharica and P. salicifolia and their cytotoxicity
Аннотация
"Phlomisspecies (Phlomis bucharicaRegel and P. salicifoliaRegel) have been traditionally used by Uzbek people as stimulant, tonic, diuretic, and in the treatment of ulcers, hemorrhoids, wounds and gynecological problems. In the present study, we characterized the chemical composition of non-polar extracts from P. bucharicaand P. salicifoliaby high resolution GLC-MS and evaluated their cytotoxicity. Concentrations of hexadecanoic acid in hexane and chloroform extracts were higher in P. bucharicathan in P. salicifolia. 1,8-Cineol, camphor, borneol, α-terpinol, thymol, and isobornyl acetate were detected in P. bucharicabut not in P. salicifolia. About 45 components were identified in P. bucharicaand 40 in P. salicifolia. The chloroform extract from P. bucharicashowed cytotoxicity in HeLa and HL-60 cells, with IC50values of 26.07 and 29.42 μg/ml, respectively."