INDICATORS OF DYNAMICAL PROINFLAMMATORY CYTOKINES IN WOMEN USING INTRAUTERINE CONTRACEPTIVES

Birth rate regulation is a major problem of modern medicine. Unfortunately, frequency of artificial abortions is still high not only in developing, but also in developed countries. Abortion results in severe gynecologic and endocrine complications in the woman’s body (Alieva, 2001).Use of intrauterine devices (IUDs) is a most effective method of contraception. A great number of studies in the field of utilization and possible complications of IUDs revealed the occurrence of inflammatory diseases of small pelvis organs (IDSPO).With this in mind, we studied the data obtained from 77 women using copper IUDs in maternity facility №2 of the city of Andizhan (Uzbekistan). Duration of patients’ follow-up ranged 40 days to 6 months. Women did not have contraindications for IUDs according to WHO medical eligibility criteria. Blood was a material for study; it was taken in 40 days, 3 and 6 months following IUD insertion. After insertion of copper IUDs to women, a cytokine cascade was studied in dynamics. The serum content of IL-1, IL-6 and concentration of TNFα was measured in all patients according to the instruction attached to immunoenzymatic analyzer "АТ-858" manufactured in China. The minimum concentration of TNFα reliably identified in this test system made 4 pg/ml.During the study, the women of the test group showed increased proinflammatory cytokines. The further study of vaginal smears confirmed development of bacterial vaginoses in them that suggests a relation of complications due to IUDs with imbalance of the cytokine cascade.Elevated serum concentration of cytokines was revealed in women with IUDs already on the first days of their application.Sharp increase in IL-1 on days 40 and 90 after insertion of IUDs is associated with presence of complications in the form of expulsions and possible development of inflammatory diseases of small pelvis organs.

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