Effectiveness of Photodynamic Therapy in the Healing of Corneal Alkali Burn in Rats
Аннотация
In this study, we investigated the effect of photodynamic therapy (PDT) on the healing of corneal alkali burns in rats. The experiment was performed on 50 adult non-linear rats. Depending on the intervention, the animals were divided into 5 equal groups with 10 animals in each group: Group 1 included rats with intact eyes (the control group) and Groups 2 through 5 were experimental groups with experimental alkali burn (EAB). Group 2 consisted of rats subjected to instillation of 0.25% chloramphenicol solution; Group 3 consisted of rats subjected to photodynamic irradiation according to our scheme: 300 mJ (630 nm) for 3 minutes; Group 4 consisted of rats subjected to instillation of methylene blue (MB); Group 5 consisted of rats subjected to instillation of MB with subsequent photodynamic irradiation according to the described scheme.