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It was performed a comparative study of the free radical oxidation parameters in various biological media in children with diseases of the respiratory system -asthma and frequent acute respiratory diseases.The study involved 215 children, who were divided into 3 groups: 58 healthy children (group 1 -control), 74 children (group 2) -frequently ill children, 83 children (group 3) -children with asthma.The changes in the indicators of free radical oxidation intranasal lavage and exhaled breath condensate groups often ill children and children with asthma are manifestations of systemic disorders in the body of patients surveyed.Similar shifts are identifi ed and in terms of the peripheral blood of these patients: in frequently ill children and children with asthma observed a signifi cant increase in the concentrations of diene conjugates and malondialdehyde relative to the control level, while the value of the activity of antioxidant enzymes superoxide dismutase and catalase were signifi cantly reduced relative the corresponding values in the control group of children.The identifi ed biochemical changes confi rm that a better balance of pro-and antioxidant systems of the body should be a prerequisite for complex treatment and preventive measures undertaken for children with common infectious diseases in the developing allergic background.

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