Searching of a Different Approach for Target Therapy of Papillary Thyroid Cancer

Among thyroid cancer papillary thyroid carcinoma is the most widely met. As it was noted below papillary carcinoma covered 90 per cent of incidents of differentiated thyroid cancer. The loss of thyroid-specific functions during tumor progression determines the resistance of thyroid tumors to traditional radioiodine therapy. Specific drugs for aggressive and metastatic thyroid cancer are required for the development of effective therapy. Tyrosine kinase inhibitors (TKIs) are emerging as new tool for aggressive thyroid cancer. Over expression of MET (mesenchymal epithelial transition) receptor is found in papillary thyroid carcinoma. We aimed to study the phosphorylation of MET in the tissue of papillary thyroid carcinoma and effect of a TKI genistein on this process. The thyroid homogenates were incubated with genistein (Sigma-Aldrich, Germany) and then the phosphorylated MET was determined by Phospho-MET ELISA Kit (Sigma-Aldrich, Germany).

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