A1036 Top nine risk factors for morbidity and mortality at patients with essential hypertension

Objectives: It is noted, that today the population of Uzbekistan unprecedentedly increases consumption of salt and have low physical activity in general. The purpose of our research was in developing the prognostic model of the turnpike arteries biological age at hypertensive patients Methods: The study included 30 healthy volunteers and 450 men with arterial hypertension AH in average age of 56.06 ± 7.86 years Results: On the basis of local research grant analysis the calculator of risk was developed to provide patients with AH I-II-degrees the important prognostic information. We also considered that population of modern Uzbekistan have tendencies of negative impact at vessels damage such as: salt and the increased body weight. As a result nine best factors for stratification of risk at patients with the defect vessels and raised SBP, including easy available, clinical parameters were included in this calculator. We applied multistage stratification of risk, based on 9 parameters which were included in the developed equation of nine factors: (a+b+s+d) x e / 100 / 2+(*m + i-18) (a-SBP; b-IM complex; s-Salt; d-smoking; e-age; *m-metabolic index *m = t x g/ h2; i-BMI; t-Triglycerides, g-Glucose; h-HDL-C). During this experiment, patients noted informational content of the calculator for the objective comprehension of their cardiovascular status (Sensitivity–85%, Specificity–63%). However long-term preventive effect, in prevention of the recurrence was not confirmed. Conclusion: On completion of the therapy clinical tests indicated the high sensitivity at average specificity model that was acceptable in an opportunity to estimate medical effect. Unfortunately, the calculator could show the rate of damage vessels in the cases of actual disease, but not in cases of its prediction or probable emergence

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