Статья

Anti-obesity Activity of Ethanol Extract from Bitter Melon in Mice Fed High-Fat Diet

Nal Ae YoonDept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University, Jinju 52727, KoreaJuyeong ParkDept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University, Jinju 52727, KoreaJoo JeongDept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University, Jinju 52727, KoreaNilufar RashidovaTashkent Medical Academy, Farabi Street 2, Tashkent 700109, UzbekistanJinhyun RyuDept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University, Jinju 52727, KoreaGu Seob RohDept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University, Jinju 52727, KoreaHyun Joon KimDept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University, Jinju 52727, KoreaGyeong Jae ChoDept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University, Jinju 52727, KoreaWan Sung ChoiDept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University, Jinju 52727, KoreaDong Hoon LeeDept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University, Jinju 52727, KoreaSang Soo KangDept. of Anatomy & Convergence Medical Science, In-stitute of Health Sciences, College of Medicine, Gyeong-sang National University, Jinju 52727, Korea

Development & Reproductionjournal2019en

ABI

Аннотация

In many cases, obesity is associated with metabolic disorders. Recently, natural compounds that may be beneficial for improving obesity have received increasing attention. Bitter melon has received attention as a diabetes treatment. NAD+-dependent deacetylase (Sirtuin 1, SIRT1) has emerged as a novel therapeutic target for metabolic diseases. In this study, ethanol extract of bitter melon (BME) suppressed adipocyte differentiation and significantly increased the expression of SIRT1 in fully differentiated 3T3-L1 cells. Moreover, it enhanced the activation of AMP-activated protein kinase (AMPK). In high-fat diet (HFD)-fed induced-obesity mice, BME suppressed HFD-induced increases in body weight and white adipose tissue (WAT) weight. BME also increased the expression of SIRT1 and suppressed peroxisome proliferator-activated receptor and sterol regulatory element binding protein 1 expressions of WAT from HFD-fed mice. These findings suggest that BME prevents obesity by activating the SIRT1 and AMPK pathway and that it may be a useful dietary supplement for preventing obesity.

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Темы

Sirtuins and Resveratrol in Medicine Biochemical effects in animals Diet, Metabolism, and Disease

Идентификаторы

DOI: 10.12717/dr.2019.23.2.129

Цитирования и источники

Цитирований: 0Использованных источников: 36

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