THE EFFECTIVENESS OF SFLT1 PROTEIN FOR THE DIAGNOSIS AND PREDICTION OF HYPERTENSIVE STATES IN PREGNANT WOMEN

Objective: Hypertensive states are still an urgent problem of modern obstetrics. Most women who have had this disease develop chronic kidney pathology, endocrine disorders, and hypertension. At present time, new stages of the pathophysiology of endothelial dysfunction in preeclampsia are described. Protein sFlt1 has been proposed as a possible factor that damages the endothelium in preeclampsia. The aim of the study was to determine the role of the sFlt1 protein for predicting the outcome of hypertensive states in pregnant women. Design and method: We studied the concentration of angiogenic soluble factor (sFlt1) in 80 women. All patients were divided into three groups. The first group consists of 25 women with a physiological pregnancy. The second group consists of 25 women with mild preeclampsia. The third group 30 women with severe preeclampsia. The age of patients ranged from 18–37 years. Results: During physiological pregnancy, the content sFlt1 was 0.16 ± 1.2 ng / ml, -1.52 ± 3.4 ng / ml with mild preeclampsia, 8, 59 ± 4.8 ng / ml with severe preeclampsia. Significant changes in the concentration of angiogenesis factor were detected in pregnant women with preeclampsia of varying severity. With the increase in the severity of preeclampsia, the concentration of the sFlt1 protein increases to 8.59 ± 4.8 ng / ml in severe preeclampsia. In pregnant women with severe preeclampsia, in parallel with the rise of blood pressure and increasing proteinuria, the concentration of sFlt1 protein in the blood increases steadily. The results of the study suggest that in the third trimester in pregnant women with a physiological course of pregnancy, as well as with preeclampsia of varying severity, there are changes in the level of angiogenesis factor. The maximum increase in sFlt1 protein concentration is observed in severe preeclampsia. In patients with mild preeclampsia, that is, with a slight increase blood pressure and proteinuria, the concentration of the angiogenic factor changes slightly. Conclusions: The results of the study showed that the determination of the level of the angiogenic protein factor sFlt1 in preeclampsia of varying degrees of severity is important for predicting pregnancy complications.

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