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Objective: To study age-dependent trends in long-term survival with its predictors in patients who underwent isolated CABG.Methods: 177 consecutive patients, operated on within 2014 were included in our study.The patients were divided into two age groups for the purposes of the statistical analysis: <60 year's (n=96), and ≥60 years (n=81).The mean age was 54.5±2.9 year's in the group of <60 years, whereas 63.6±2.5 in the ≥60 years.In both groups, the impact of the prevalence of comorbidities, severity of coronary lesion, revascularization degree (complete/incomplete) on postoperative outcome was assessed.Furthermore, the whole predictors of mortality were identified according to both age groups by means of multivariate analysis.End point of this study was overall survival.All data were obtained from patients' medical, out-patient follow-up records, operative reports. Results:The mean follow-up of the overall cohort was 5.1±1.7 years.Chronic pulmonary disease, extracardiac arteriopathy, and neurologic dysfunction disease were significantly less frequent in the group of <60 years, whereas the prevalence of BMI ≥30, unstable angina, previous myocardial infarction, and preoperative severe depressed left ventricular ejection fraction were significantly higher in this population.At 5 years follow-up, survival rate was 94.8% in patients under 60 years (5 patients), 90.1% (8 patients) in those aged 60 and more year's (p<0.001).By multivariate analysis, previous myocardial infarction, chronic renal failure, diabetes, chronic pulmonary disease, extracardiac arteriopathy and left main coronary artery disease were considered as independent predictors of mortality.The area under the receiver operating characteristic curve was 0.834 (p<0.001,95% CI: 0.724-0.902). Conclusion:Despite the coronary artery bypass grafting are more secure for both groups, a strict attention should be focused in order to design and improve preventive strategies aiming to reduce the impact of specific cardiovascular risk factors on younger patients, such as diet, lifestyle, weight control and more aggressive medical therapy.The reasonable revascularization strategy with its underscored threshold for elderly patients with multivessel and left main coronary artery diseases, potential risk factors for death as concomitant pathologies should be elaborated.

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