The role of liver in modifi cation of peptidergic mechanisms of regulation of digestive glands

Studies were performed on 84 rats in 12 series, 7 acute experiments in each series. Studied the change in gastric and pancreatic secretion with the introduction of the short-chain peptide CCK-8 and pentagastrin in the presence of trypsin and contrуcal. It was concluded that the short-chain peptide CCK-8 and pentagastrin are utilized by the liver to a large extent. Trypsin, when passing through the liver, reduces the ability of the liver to utilize CCK-8 and pentagastrin. The protease inhibitor contrуkal ® when passing through the liver increases the ability of the liver to utilize these peptides. It is concluded that the liver is involved in the modifi cation of peptidergic mechanisms of regulation of the digestive glands.

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