The Rate and Structure of Causes in Development of Secondary Metabolic Nephropathy in Children
Аннотация
Metabolic disorders nephropathy (MDN) is a large group of kidney diseases with various etiologies and pathogenesis, but combined in that their development is associated with metabolic disorders that can lead to changes in the functional state of the kidneys or structural changes at the level of various structures of the nephron. Statistical variation in the registration of MDN ranges from 27% to 64% in the structure of the incidence of the urinary system in children, and in everyday practice of a pediatrician, almost every third patient has a syndrome of metabolic disorders in the urine. Establishing the nature of crystalluria as the cause of metabolic nephropathy, at what age the manifestations of MDN most often debut, the gender characteristics of this pathology, and finally, the determination of the genealogical relationship is a widely discussed focus of research on this field. Therefore, our results showed that oxalate-calcium crystalluria accounted for the majority of cases of crystalluria, especially from 6 months to 7 years of age, which predetermined the majority of cases of secondary oxalate nephropathy, especially in boys who had a longer course of oxaluria. Genealogical analysis of anamnestic data reflected the high incidence of kidney stones diseases and dysuric syndrome, which correlated with a hereditary burden in the gastrointestinal tract, among parents and immediate relatives of the studied children with SMN.