PLGF/ SFLT-1 Concentrations As Early Predictors Preeclampsia In Pregnancy During Pandemic Covid-19

The imbalance in placenta-originated angiogenic factors has been found to play an important role in the pathogenesis of preeclampsia in recent years.Soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PIGF) are the most studied proteins.sFlt-1, a splice variant of the vascular endothelial growth factor (VEGF) receptor Flt-1, is a circulating antiangiogenic protein that inhibits proangiogenic factors-VEGF and PIGF signalling in the vasculature.High levels of circulating sFlt-1 and low levels of PIGF were observed in women with established preeclampsia and even before the onset of clinical symptoms [1,6,9,11].

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