Статья

Analysis of influence of background therapy for comorbidities in the period before infection on the risk of the lethal COVID outcome. Data from the international ACTIV SARS-CoV-2 registry («Analysis of chronic non-infectious diseases dynamics after COVID-19 infection in adult patients SARS-CoV-2»)

E. I. TarlovskayaEurasian Association of Therapists, Moscow; Privolzhsky Research Medical University, Nizhny NovgorodA. G. ArutyunovEurasian Association of Therapists, Moscow; N. I. Pirogov Russian National Research Medical University, MoscowА. О. КонрадиV. A. Almazov National Medical Research Center, St. PeterburgYu. M. LopatinVolgograd State Medical University, VolgogradА. П. РебровV. I. Razumovsky Saratov State Medical University, SaratovС. Н. ТерещенкоNational Medical Research Center of Cardiology, MoscowА. И. ЧесниковаRostov State Medical University, Rostov-on-DonHamlet HayrapetyanErebouni Medical Center, Cardiology and Cardiac Surgery Clinic, ErevanA. P. BabinNikolae Testemitanu Sate University of Medicine and Pharmacy, KishinevИ. Г. БакулинI. I. Mechnikov North-Western State Medical University, St. PetersburgН. В. БакулинаI. I. Mechnikov North-Western State Medical University, St. PetersburgЛ. А. БалыковаN. P. Ogarev National Research Mordovia State University, SaranskА. С. БлагонравоваPrivolzhsky Research Medical University, Nizhny NovgorodМ. В. БолдинаPrivolzhsky Research Medical University, Nizhny NovgorodА. Р. ВайсбергPrivolzhsky Research Medical University, Nizhny NovgorodА. S. GalyavichInterregional Clinical Diagnostic Center, Kazan; Kazan State Medical University, KazanV. V. GomonovaI. I. Mechnikov North-Western State Medical University, St. PetersburgN. Yu. GrigorievaN. I. Lobachevsky National Research State University of Nizhny Novgorod, Nizhny NovgorodИ. В. ГубареваSamara State Medical University, SamaraИ. В. ДемкоKrasnoyarsk Regional Clinical Hospital, KrasnoyarskA. V. EvzerikhinaKrasnogorsk Municipal Hospital №1, KrasnogorskА. В. ЖарковU. K. KamilovaNational Specialized Science and Practice Medical Center for Therapy and Medical Rehabilitation, TashkentZ. F. KimТ. Yu. KuznetsovaPetrozavodsk State University, PetrozavodskН. В. ЛареваChita State Medical Academy, ChitaЕ. В. МакароваPrivolzhsky Research Medical University, Nizhny NovgorodS. V. MalchikovaKirov State Medical University, KirovС. В. НедогодаVolgograd State Medical University, VolgogradМ. М. ПетроваProf. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, KrasnoyarskИ. Г. ПочинкаPrivolzhsky Research Medical University, Nizhny Novgorod; Municipal Clinical Hospital #13 of the Nizhny Novgorod Avtozavodsky District, Nizhny NovgorodК. В. ПротасовIrkutsk State Medical Academy of Postgraduate Education, Branch of the Russian Medical Academy of Continuing Professional Education, IrkutskД. Н. ПроценкоD. Yu. RuzanauGomel State Medical University, GomeS. A. SayganovI. I. Mechnikov North-Western State Medical University, St. PetersburgAkpay SarybaevM. M. Mirrakhimov National Center of Cardiology and Therapy, BishkekН. М. СелезневаN. P. Ogarev National Research Mordovia State University, SaranskA. B. SugralievS. D. Asfendiyarov Kazakh National Medical University, Alma-AtaИ. В. ФоминPrivolzhsky Research Medical University, Nizhny NovgorodО. В. ХлыноваAkademician E. A. Vagner Perm State Medical University, PermO. Yu. ChizhovaI. I. Mechnikov North-Western State Medical University, St. PetersburgИ. И. ШапошникSouth Ural State Medical University, ChelyabinskD. A. ShсukarevA. K. AbdrahmanovaKazakh Medical University of Continuous Education, Alma-Ata; I. Zhekenova Municipal Clinical Hospital for Infectious Diseases, Alma-AtaS. A. AvetisianErebouni Medical Center, Cardiology and Cardiac Surgery Clinic, ErevanH. G. AvoyanErebouni Medical Center, Cardiology and Cardiac Surgery Clinic, ErevanK. K. AzarianErebouni Medical Center, Cardiology and Cardiac Surgery Clinic, ErevanG. T. AimakhanovaS. D. Asfendiyarov Kazakh National Medical University, Alma-AtaD. A. AyipovaM. M. Mirrakhimov National Center of Cardiology and Therapy, BishkekA. Ch. AkunovM. M. Mirrakhimov National Center of Cardiology and Therapy, BishkekM. K. AlievaI. I. Mechnikov North-Western State Medical University, St. PetersburgА. В. АпаркинаV. I. Razumovsky Saratov State Medical University, SaratovО. Р. АруслановаE. Yu. AshinaPrivolzhsky Research Medical University, Nizhny NovgorodO. Yu. BadinaO. Yu. BarishevaPetrozavodsk State University, PetrozavodskA. S. BatchayevaN. I. Pirogov Russian National Research Medical University, MoscowA. M. BitievaI. I. Mechnikov North-Western State Medical University, St. PetersburgI. U. BikhteyevI. I. Mechnikov North-Western State Medical University, St. PetersburgN. A. BorodulinaM. V. BraginI. I. Mechnikov North-Western State Medical University, St. PetersburgA. M. BuduMunicipal Clinical Hospital №1, KishinevЛ А БурыгинаG. A. BykovaAkademician E. A. Vagner Perm State Medical University, PermK. R. VagapovaPolyclinic №1 at the Administrative Department of the President of the Russian Federation, MoscowД. Д. ВарламоваPetrozavodsk State University, PetrozavodskН. Н. ВезиковаPetrozavodsk State University, PetrozavodskЕ. A. VerbitskayaProf. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, KrasnoyarskО. Е. ВилковаN. I. Lobachevsky National Research State University of Nizhny Novgorod, Nizhny NovgorodЕ. А. ВинниковаI. I. Mechnikov North-Western State Medical University, St. PetersburgВ. В. ВустинаPerm Regional Clinical Hospital, PermЕ. А. ГаловаPrivolzhsky Research Medical University, Nizhny NovgorodV. V. GenkelSouth Ural State Medical University, ChelyabinskЕ. И. ГоршенинаN. P. Ogarev National Research Mordovia State University, SaranskR. V. GostishevE. V. GrigoryevaV. I. Razumovsky Saratov State Medical University, SaratovE. Yu. GubarevaSamara State Medical University, SamaraG. M. DabylovaS. D. Asfendiyarov Kazakh National Medical University, Alma-AtaA. I. DemchenkoSamara State Medical University, SamaraO. Yu. DolgikhChapaevsk Central Municipal Hospital, ChapaevskM. Y. DuyshobayevS. D. Asfendiyarov Kazakh National Medical University, Alma-AtaД. С. ЕвдокимовI. I. Mechnikov North-Western State Medical University, St. PetersburgК. Е. ЕгороваV. A Baranov Karelia Republic Hospital, PetrozavodskA. N. ErmilovaEurasian Association of Therapists, Moscow; V. P. Serbsky National Medical Research Center of Psychiatry and Narcology, MoscowA. E. ZheldybayevaS. D. Asfendiyarov Kazakh National Medical University, Alma-AtaН. В. ЗаречноваYu. D. ZiminaMunicipal Clinical Hospital №25, NovosibirskS. Yu. IvanovaHospital for Veterans of Wars, PetrozavodskE. Yu. IvanchenkoPrivolzhsky Research Medical University, Nizhny NovgorodM. V. IlinaM. V. KazakovtsevaKirov State Medical University, KirovE. V. KazymovaClinical Hospital at the Samara Station “Russian Railways Medicine”, SamaraYu. S. KalininaProf. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, KrasnoyarskN. A. KamardinaА. М. KarachenovaChita State Medical Academy, ChitaИ. А. КаретниковIrkutsk Regional Clinical Hospital, recipient of the “Badge of Honor” award, IrkutskН. А. КаролиV. I. Razumovsky Saratov State Medical University, SaratovO. V. KarpovM. Kh. KarsievI. I. Mechnikov North-Western State Medical University, St. PetersburgД. С. КаскаеваProf. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk

Kardiologiiajournal2021en

ABI

Аннотация

Aim To study the effect of regular drug therapy for cardiovascular and other diseases preceding the COVID-19 infection on severity and outcome of COVID-19 based on data of the ACTIVE (Analysis of dynamics of Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.Material and methods The ACTIVE registry was created at the initiative of the Eurasian Association of Therapists. The registry includes 5 808 male and female patients diagnosed with COVID-19 treated in a hospital or at home with a due protection of patients' privacy (data of nasal and throat smears; antibody titer; typical CT imaging features). The register territory included 7 countries: the Russian Federation, the Republic of Armenia, the Republic of Belarus, the Republic of Kazakhstan, the Kyrgyz Republic, the Republic of Moldova, and the Republic of Uzbekistan. The registry design: a closed, multicenter registry with two nonoverlapping arms (outpatient arm and in-patient arm). The registry scheduled 6 visits, 3 in-person visits during the acute period and 3 virtual visits (telephone calls) at 3, 6, and 12 mos. Patient enrollment started on June 29, 2020 and was completed on October 29, 2020. The registry completion is scheduled for October 29, 2022. The registry ID: ClinicalTrials.gov: NCT04492384. In this fragment of the study of registry data, the work group analyzed the effect of therapy for comorbidities at baseline on severity and outcomes of the novel coronavirus infection. The study population included only the patients who took their medicines on a regular basis while the comparison population consisted of noncompliant patients (irregular drug intake or not taking drugs at all despite indications for the treatment).Results The analysis of the ACTIVE registry database included 5808 patients. The vast majority of patients with COVID-19 had comorbidities with prevalence of cardiovascular diseases. Medicines used for the treatment of COVID-19 comorbidities influenced the course of the infectious disease in different ways. A lower risk of fatal outcome was associated with the statin treatment in patients with ischemic heart disease (IHD); with angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor antagonists and with beta-blockers in patients with IHD, arterial hypertension, chronic heart failure (CHF), and atrial fibrillation; with oral anticoagulants (OAC), primarily direct OAC, clopidogrel/prasugrel/ticagrelor in patients with IHD; with oral antihyperglycemic therapy in patients with type 2 diabetes mellitus (DM); and with long-acting insulins in patients with type 1 DM. A higher risk of fatal outcome was associated with the spironolactone treatment in patients with CHF and with inhaled corticosteroids (iCS) in patients with chronic obstructive pulmonary disease (COPD).Conclusion In the epoch of COVID-19 pandemic, a lower risk of severe course of the coronavirus infection was observed for patients with chronic noninfectious comorbidities highly compliant with the base treatment of the comorbidity.

Темы

Long-Term Effects of COVID-19 Healthcare Systems and Public Health Human Health and Disease

Идентификаторы

DOI: 10.18087/cardio.2021.9.n1680

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Цитирований: 0Использованных источников: 35

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