FEATURES OF MICROCIRCULATORY LIVER DISORDERS ON THE BACKGROUND OF HEMORHEOLOGICAL DISORDERS IN THE DEVELOPMENT OF HYPOXIC AND HEMIC HYPOXIA

He state of the microvasculature of the liver has been studied, and a quantitative assessment of the changes occurring during hypoxic and hemic experimental hypoxia is given. A comprehensive analysis of the state of rheological properties of blood in close relationship with the properties of dynamic viscosity and shear rate of blood in hypoxic and hemic experimental hypoxia is presented. According to the results of the study, it can be assumed that in the initial stages of hypoxemia, the liver largely compensates for the lack of oxygen in the flowing blood by increasing its extraction. With hypoxia, taking into account the characteristics of the hepatic blood flow, one can assume an important role of circulatory disorders in the pathological processes developing in the liver with severe forms of hypoxia. The regular increase in blood viscosity revealed in severe forms of hypoxia at velocity gradients simulating the conditions of blood flow in microvessels was a direct confirmation of the emerging microcirculatory disorders. Taking them into account is important for understanding the pathogenesis of developing pathological changes in the liver.

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