Endothelial dysfunction as a link in the pathogenesis of ankylosing spondylitis against the background of a new coronavirus infection

AbstractThe main purpose of this work was to substantiate the feasibility and possible directions of the influence of means of pharmacological correction of endothelial dysfunction for the prevention of pathological conditions associated with a new coronavirus infection. Theanalysis of the available literature on the functions of the endothelium was carried out, the study of foreign and domestic experience on the possible directions of pharmacological correction of endothelial dysfunction was carried out. A review of the available literature data on endothelial dysfunction with substantiation of the role of vascular endothelial damage as one of the central links in the pathogenesis of acute respiratory distress syndrome is presented. The phases of the formation of stages of endothelial dysfunction are shown, the mechanisms of endothelial damage in a new coronavirus infection are determined. Possible directions for the pharmacological correction of endothelial dysfunction are proposed, which will prevent the risk of complications from a new coronavirus infection, including through the development of path genetically grounded directions of pharmacotherapy.

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