Effect of stimulation of α2-Adrenoceptor on the isolated rat heart after limitation of motor activity

The study of the effect of limiting motor activity on the body and organ systems is an urgent task. The importance of this issue is due to not only the modern lifestyle but also the high prevalence of hypokinesia in medical practice (prolonged bed rest due to fractures, diseases of the cardiovascular system, and other diseases). The functional role of α-adrenergic re-ceptors in adapting the cardiovascular system to changes in the motor regime requires further study. The study of the mechanisms of hypokinetic disorders, the development of methods, and means of prevention and correction of their consequences are of great social importance. Based on the <br> foregoing, the question of the functional significance of α2-adrenergic receptors in the heart with a change in the motor regime remains relevant. This experiment was carried out on outbred white rats growing under conditions of limited physi-cal activity for 30 days. A Langendorff prepararion study of <br> the effect of a α2-adrenergic receptor agonist on the function-al parameters of the isolated heart of rats (LVP, HR, CF) was <br> carried out. To stimulate α2-adrenergic receptors, a pharma-cological agent, clonidine hydrochloride, was used at concen-trations from М to М. Stimulation of α2-adrenergic receptors led to an increase in the contraction force of the isolated heart, except for the concentration М, which had the opposite effect. Application of clonidine, in hypoki-nesized rats developed bradycardia and a decrease in the coronary blood flow of the isolated heart.

Перевод пока недоступен