The Effect of Nutritional Additive of Glycyrrizic Acid, Glabridin and Resveratrol on SARS-coronavirus Replication

The outbreak of SARS requires the search for antiviral compounds to prevent and treat this disease. Currently, there is no specific treatment for coronavirus infection associated with SARS-COVID-19. Among researchers working in this area, there are various approaches to create an effective vaccine against this infection, there is no consensus on this problem. We will assess the antiviral potential of GA, GL, RT against two clinical isolates of coronavirus (M-1 and M-2) from SARS patients admitted to the Bukhara Multifunctional Clinical Center. The chemical structure of these substances interacts with the structures of the virus, changing the various phases of the viral cycle, which is accompanied by irreversible inactivation of viral particles (which are in a free state outside the cells), blocking the introduction of active viral particles through the cell membrane into the cell, as well as disrupting the ability of viruses to synthesize new structural components. Inhibits viruses at concentrations that are non-toxic to normally functioning cells. All these properties of these substances have attracted our attention, and some of them have confirmed their importance. Our results indicate that GA and RT should be used to treat coronavirus infection. RT, in turn, has antiviral, anticancer effects and will also be studied in detail.

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