Allergen-specific immunotherapy in children with allergic rhinitis

Results: Positive results were observed in 14 children (87.5%) with intermittent allergic rhinitis from the 1st group and 13 children (86.6%) with persisting allergic rhinitis from the 2nd group after ASIT sublingual courses (р <0.05). Complete clinical remission in 100% of the children in the 1st group with intermittent allergic rhinitis was confirmed by positive dynamics observed after the 2nd and 3rd courses of ASIT; a very strong correlation r= 0.946 was determined, р <0.01. Among the patients of the 2nd group with persisting allergic rhinitis we did not observe complete clinic remission, though 11 (73.3%) of them had a positive tendency (partial clinic remission) after ASIT.\n\nAmong the problems of modern allergology the problem of allergic rhinitis (AR) in children occupies a special place [1,5,9,11]. Allergic rhinitis is one of allergic diseases with a great prevalence rate in childhood [2,3,12,22]. This pathology is considered to be a global problem, as it is of a high rank in the system of allergic pathologies (60-70%); its high prevalence (10-15%) in pediatric population also confirms the significance of the problem [4,6,10,16].\n\nContinuous growth of the number of sick children in most countries of the world is conditioned by wrong interpretation of the disease manifestations, late application for medical help, late diagnosis and therapy.\n\nBeing the most effective therapy for allergic diseases, allergen-specific immune therapy (ASIT) is an introduction of a small dose of the allergen responsible for the development of the disease to a certain patient [5,7,8,14,18,20]. In that condition sensitivity of the body to that antigen decreases. The history of ASIT application is over 100 years old and within that period a great evidence base of the therapeutic method application was collected [3,13,15,17,19,21]. Due to decrease of disease manifestations, diminished need in therapy and in addition to that prevention of further development of allergy and its symptoms ASIT provides long-lasting clinical effect. The therapy affects essential immunologic mechanisms responsible for the development of clinical symptoms.\n\nThe objective: to study progression of allergic rhinitis in children and to assess the efficacy of ASIT.

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