Markers of systemic inflammation in patients with chronic kidney disease
Аннотация
Abstract. In view of the fact that the human microbiota varies depending on many factors, including comorbid pathology, it seems reasonable to investigate the intestinal microbiota in patients with chronic kidney disease and its likely relationship with markers of systemic inflammation. Studies have shown a relationship between several biomarkers of inflammation with changes in the composition of the intestinal microbiota in patients with chronic kidney disease. The study included 85 patients with CKD. The average age of the patients was 52 ± 4 years (48 men and 37 women). The control group consisted of 30 healthy volunteers aged 50 ± 3 years, 15 men and 15 women, comparable to the main group in terms of sex and age. The results of the study demonstrated that in patients with CKD, an imbalance of the intestinal microbiota is combined with an increased level of CRP, IL-6, and IL-10 leukocytes. There is a bi-directional relationship in which inflammation and dysbiosis contribute to the progression of chronic kidney disease. The study of markers responsible for pro-inflammatory effects in the body showed that such indicators as IL-6, IL-10, CRP, fibrinogen showed a significant correlation with the composition of the microbiota in patients with CKD.