Clinical-morphological, morphofunctional and immunohistochemical characteristics of facial skin in normal conditions and with various forms of actinic keratosis

One of the main problems of modern medicine is the steady growth of malignant neoplasms of the skin, which occupy 2-3 places in the structure of oncological morbidity, accounting for 1112%. Certain types of malignant skin tumors, as a rule, develop at the site of long-standing background conditions. Therefore, the most effective way to combat them is prevention, timely diagnosis, and treatment of precancerous diseases. An optional precancer is an actinic keratosis (AK), which is areas of local intraepidermal atypia of keratinocytes, localized in open areas of the body, exposed to excessive insolation, and showing signs of "solar" elastosis [Galil-Ogly GA, 2005; Salasche S. J., 2000]. With the long-term existence of foci, the transformation of AK into squamous cell or basal cell skin cancer is possible in 0.1% - 20% of cases [Alam M., 2006; Bui M.N., 2004; Moul JW 1996; Saarialho-Kere U, 1999]. As a rule, transformation develops in certain histological types of AK (bowenoid and proliferative), which are characterized by a high degree of dysplastic changes in the epidermis [Suchniak J.M., 1997].

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