Advancing the global public health agenda for NAFLD: a consensus statement
Jeffrey V. LazarusBarcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain. [email protected]Henry E. MarkQuentin M. AnsteeNewcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UKJuan Pablo ArabDepartamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, ChileRachel L. BatterhamCentre for Obesity Research, University College London and National Institute of Health Research, UCLH Biomedical Research Centre, London, UKLaurent CastéraDepartment of Hepatology, Hôpital Beaujon, Université de Paris, Paris, FranceHelena Cortez‐PintoClínica Universitária de Gastrenterologia, Laboratório de Nutrição, Faculdade de Medicina, Universidade de Lisboa, Lisbon, PortugalJavier CrespoGastroenterology and Heptology Unit, Hospital Universitario Marqués de Valdecilla, Santander, IDIVAL, Santander, SpainKenneth CusiDivision of Endocrinology, Diabetes & Metabolism, Department of Medicine, Veterans Health Administration and University of Florida, Gainesville, FL, USAM. Ashworth DiracDepartment of Health Metrics Sciences, Department of Family Medicine, University of Washington, Seattle, WA, USASven FrancqueDepartment of Gastroenterology Hepatology, University Hospital Antwerp, Antwerp, BelgiumJacob GeorgeStorr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, New South Wales, AustraliaHannes HagströmDepartment of Medicine, Karolinska Institutet, Stockholm, SwedenTerry T.‐K. HuangCenter for Systems and Community Design and NYU-CUNY Prevention Research Center, Graduate School of Public Health and Health Policy, City University of New York, New York, NY, USAMona IsmailDivision of Gastroenterology, Department of Internal Medicine, King Fahd Hospital of the University, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi ArabiaAchim KautzKautz5, Köln, GermanyShiv Kumar SarinDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, IndiaRohit LoombaDepartment of Medicine, NAFLD Research Center, La Jolla, CA, USAVeronica MillerUniversity of California Berkeley, School of Public Health, Forum for Collaborative Research, Washington, DC, USAPhilip N. NewsomeNational Institute for Health Research Birmingham Biomedical Research Centre at University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham, Birmingham, UKMichael NinburgHepatitis Education Project, Seattle, WA, USAPonsiano OcamaDepartment of Medicine, College of Health Sciences, Makerere University, Kampala, UgandaVlad RatziuAssistance Publique-Hôpitaux de Paris, Hôpital Pitie-Salpetriere, University of Paris, Paris, FranceMary E. RinellaDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USADiana RomeroDepartment of Community Health and Social Sciences, CUNY Graduate School of Public Health and Health Policy, New York, NY, USAManuel Romero‐GómezUCM Digestive Diseases, CIBEREHD and IBIS, Virgen del Rocío University Hospital, University of Seville, Seville, SpainJörn M. SchattenbergMetabolic Liver Research Program, I. Department of Medicine, University Medical Centre Mainz, Mainz, GermanyEmmanuel TsochatzisSheila Sherlock Liver Centre, Royal Free Hospital, London, UKLuca ValentiDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, ItalyVincent Wai‐Sun WongDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, ChinaYusuf YılmazDepartment of Gastroenterology, Marmara University School of Medicine, Istanbul, TurkeyZobair M. YounossiShira Zelber‐SagiDepartment of Gastroenterology, Tel-Aviv Medical Centre, Tel-Aviv, IsraelFredrik ÅbergTransplantation and Liver Surgery, Helsinki University Hospital, Helsinki, FinlandLeon A. AdamsUniversity of Western Australia, Perth, Western Australia, AustraliaMaryam Salem Al KhatryKhalid Al NaamaniArmed Forces Hospital, Muscat, OmanOmar Alfaro MurilloAlina M. AllenMayo Clinic, Rochester, NY, USAFaisal Abdullatif AlnaserHome Health Care Centre, Maqabah, BahrainSaleh A. AlqahtaniLiver Transplant Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi ArabiaKhalid AlswatLiver Disease Research Center, College of Medicine, King Saud University, Riyadh, Saudi ArabiaDomenico AlvaroSapienza University of Rome, Rome, ItalyRaúl J. AndradeCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, SpainMarco ArreseDepartamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, ChileYaw Asante AwukuUniversity of Health and Allied Sciences, Ho, GhanaMotala AyeshaUniversity of KwaZulu-Natal, Durban, South AfricaOidov BaatarkhuuMongolian National University of Medical Sciences, Ulaanbaatar, MongoliaShokhista BakievaResearch Institute of Virology of the Ministry of Health of the Republic of Uzbekistan, Tashkent, UzbekistanRita BasuUniversity of Virginia, Charlottesville, VA, USARamón BatallerUniversity of Pittsburgh, Pittsburgh, PA, USAShahinaz BedriNational Public Health Laboratory of Sudan and Ahfad University for Women, Khartoum, SudanEmanuele BosiDiabetes Research Institute, San Raffaele Hospital and San Raffaele Vita Salute University, Milan, ItalyMarc BourlièreSaint Joseph Hospital Marseille, Marseille, FranceRadan BrůhaGeneral University Hospital and Charles University, Prague, Czech RepublicElisabetta BugianesiDepartment of Medical Sciences, University of Turin, Turin, ItalyPatrizia BurraUniversity of Padua-Italy, Padua, ItalyMarı́a ButiVall d'Hebron University Hospital, Barcelona, SpainChristopher D. ByrneSouthampton National Institute for Health Research Biomedical Research Centre and the Institute of Developmental Sciences, University of Southampton, Southampton, UKJosé Luís CallejaHospital University of Puerta de Hierro, Majadahonda, SpainPatrizia CarrieriAix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, Marseille, FranceFlloyd CarterUniversity of the West Indies, Nassau, BahamasMarlén Ivón Castellanos FernándezInstitute of Gastroenterology, Medical University of Havana, Havana, CubaGabriela Castillo-LopezBuenos Aires University, Buenos Aires, ArgentinaGraciela Castro‐NarroHenry Lik‐Yuen ChanUnion Hospital, Hong Kong, ChinaWah‐Kheong ChanGastroenterology and Hepatology Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, MalaysiaYoosoo ChangCenter for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaMassimo ColomboKirsten J. CoppellDepartment of Medicine, University of Otago, Dunedin, New ZealandKathleen E. CoreyMassachusetts General Hospital and Harvard Medical School, Boston, MA, USAAntonio Craxı̀University of Palermo, Palermo, ItalyDonna R. CryerGlobal Liver Institute, Washington, DC, USAAnuradha Supun DassanayakeUniversity of Kelaniaya, Colombo, Sri LankaAntonieta de Ascenção Soares MartinsUniversity of Cabo Verde, Praia, Cabo VerdeVictor de LédinghenHospital Center University of Bordeaux, Bordeaux, FranceStefano DelPratoUniversity of Pisa, Pisa, ItalySandro DemaioVicHealth, Melbourne, Victoria, AustraliaHailemichael DesalegnSt. Paul's Hospital Millennium Medical College, Addis Ababa, EthiopiaJohn DillonUniversity of Dundee, Dundee, UKAjay DusejaPostgraduate Institute of Medical Education and Research, Chandigarh, IndiaPrabhakaran DorairajWorld Heart Federation, Geneva, SwitzerlandMattias EkstedtDepartment of Health, Medicine and Caring Sciences, Linköping University, Linköping, SwedenMohamed El‐KassasEndemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, EgyptOsama Mohamed ElsanousiThe National Ribat University, Khartoum, SudanGamal EsmatCairo University Hospitals, Cairo, EgyptJian‐Gao FanDepartment of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaNathalie J. Farpour‐LambertEuropean Association for the Study of Obesity (EASO), Teddington, UKRobert FlisiakMedical University of Bialystok, Bialystok, PolandYasser FouadMinia University, Minia, EgyptMichael FuchsVirginia Commonwealth University and Central Virginia Veterans Affairs Health Systems, Richmond, VA, USARino Alvani GaniHepatobiliary Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, IndonesiaLynn H. GerberInova Health System, Falls Church, VA, USAHasmik GhazinyanLiana GheorgheUniversity of Medicine and Pharmacy Carol Davila, Bucharest, RomaniaGeorge Boon‐Bee GohDepartment of Gastroenterology & Hepatology, Singapore General Hospital, Singapore, SingaporeHenning GrønbækDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, DenmarkAghayeva GulnaraSaeed HamidAga Khan University, Karachi, PakistanVanessa Hebditch
ABI
Аннотация
Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects approximately one-quarter of the global adult population, causing a substantial burden of ill health with wide-ranging social and economic implications. It is a multisystem disease and is considered the hepatic component of metabolic syndrome. Unlike other highly prevalent conditions, NAFLD has received little attention from the global public health community. Health system and public health responses to NAFLD have been weak and fragmented, and, despite its pervasiveness, NAFLD is largely unknown outside hepatology and gastroenterology. There is only a nascent global public health movement addressing NAFLD, and the disease is absent from nearly all national and international strategies and policies for non-communicable diseases, including obesity. In this global Delphi study, a multidisciplinary group of experts developed consensus statements and recommendations, which a larger group of collaborators reviewed over three rounds until consensus was achieved. The resulting consensus statements and recommendations address a broad range of topics - from epidemiology, awareness, care and treatment to public health policies and leadership - that have general relevance for policy-makers, health-care practitioners, civil society groups, research institutions and affected populations. These recommendations should provide a strong foundation for a comprehensive public health response to NAFLD.
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