Anionic Favipiravir in Salt-type Cocrystals with Monoethanolamine and Ethylenediamine
Odil ChorievInstitute of General and Inorganic Chemistry, Uzbekistan Academy of SciencesJamshid AshurovInstitute of Bioorganic Chemistry, Uzbekistan Academy of SciencesAziz B. IbragimovInstitute of General and Inorganic Chemistry, Uzbekistan Academy of SciencesShukhrat TuraboevInstitute of Bioorganic Chemistry, Uzbekistan Academy of SciencesVahobjon Kh. SabirovInstitute of Bioorganic Chemistry, Uzbekistan Academy of Sciences
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Аннотация
Salt-like cocrystals of favipiravir (FVR) with monoethanolamine (MEA) (I) and ethylendiamine (en) (II) have been determined by X-ray crystallography. The crystallographic data are (1), monoclinic P21/c, Z = 4, a = 12.2433(3), b = 22.5400(5), c = 7.3223(3)Å, β = 106.287(3)°, V = 1939.6(1)Å, R1 = 0.0499; (II), triclinic P1, Z = 2, a = 8.5903(12), b = 9.4980(10), c = 10.0337(13), α = 83.464(10), β = 79.338(11), γ = 80.665(10)Å, V = 790.90(18)Å3, R = 0.0709. In both of compounds, FVR is a single charged anion with a deprotonated 2-hydroxyl group. The asymmetric unit of the lattice consists: (1) of two FVR anion and two MEA cations; (2) of two FVR anions and one a double charged en cation.
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