Статья

RETRACTED: Synthesis of Bioactive Yttrium-Metal–Organic Framework as Efficient Nanocatalyst in Synthesis of Novel Pyrazolopyranopyrimidine Derivatives and Evaluation of Anticancer Activity

Raed Obaid SalehDepartment of Pharmacy, Al-Maarif University College, Al-Anbar, IraqHarun AchmadDepartment of Pediatric Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar, IndonesiaBotir DaminovTashkent Pediatric Medical Institute, Tashkent, UzbekistanHamzah H. KzarVeterinary Medicine College, Al-Qasim Green University, Al-Qasim, IraqAhmed B. MahdiAli Thaeer HammidComputer Engineering Techniques Department, Faculty of Information Technology, Imam Ja’afar Al-Sadiq University, Baghdad, IraqMohammed Kadhem AbidDepartment of Anesthesia, College of Health and Medical Technology, Al-Ayen University, Thi-Qar, IraqMaria Jade Catalan OpulenciaCollege of Business Administration, Ajman University, Ajman, United Arab EmiratesYasser Fakri MustafaDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, IraqHimanshu SharmaDepartment of Computer Engineering and Applications, GLA University, Mathura, India

Frontiers in Chemistryjournal2022en

ABI

Аннотация

Novel Yttrium-metal–organic framework (Y-MOF) was synthesized under optimal conditions of microwave with a power of 20 W, the temperature of 30 degrees of centigrade, and time duration of 10 min. The products were characterized by SEM (morphology and size distribution), TGA (thermal stability), BET technique (surface area), and FTIR (characterization of the related group). The Yttrium-metal–organic framework (Y-MOF) synthesized in this study, after identifying and confirming the structure, was used as an efficient and recyclable catalyst in the synthesis of new pyrazolopyranopyrimidine derivatives. Following the study of the properties and applications of Y-MOF, its anticancer properties on breast cancer cells based on the MTT method were evaluated, and significant results were observed. In addition, the anticancer properties of the pyrazolopyranopyrimidine derivatives were investigated.

Темы

Multicomponent Synthesis of Heterocycles Synthesis and biological activity Metal-Organic Frameworks: Synthesis and Applications

Идентификаторы

DOI: 10.3389/fchem.2022.928047

Цитирования и источники

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