NASOPHARYNGEAL EXTRACTION OF S. PNEUMONIAE FROM ADULT PATIENTS WITH ACUTE RESPIRATORY INFECTIONS AND ANTIBIOTIC RESISTANCE OF ISOLATED STRAINS.

Objective: To study the frequency of S. pneumoniae nasopharyngeal shedding in adult patients with acute respiratory infections and to determine their sensitivity to antimicrobial drugs.\n\nMaterial and methods: a bacteriological study was carried out on 240 samples of nasopharyngeal mucus taken from patients with a diagnosis of "Acute respiratory infection" aged 18 years and older who were in inpatient treatment at the City Clinical Infectious Diseases Hospital No. 1 in Tashkent (CCIDH No. 1). Determination of sensitivity to antimicrobial drugs was carried out by the disk-diffusion method and the E-test method. The data were interpreted according to the recommendations of the European Committee for the determination of antimicrobial susceptibility (EUCAST).\n\nResults and discussion: from all examined 240/100% of patients with acute respiratory infections of the upper and lower respiratory tract, S. pneumoniae was isolated from nasopharyngeal mucus in 56 / 23.3% of patients. The most significant factors in maintaining the carriage of S. pneumoniae were such factors as chronic diseases of the ENT organs, unsatisfactory living conditions, and bad habits. The obtained isolates of S. pneumoniae in 73.3% of cases retained sensitivity to penicillin, in 26.7% of the strains were resistant. Also, resistant strains were detected in 25.8% of isolates to azithromycin and in 27.3% to erythromycin.\n\nConclusions: In patients with ARI, from whose nasopharyngeal mucus S. pneumoniae was isolated, 66.1% of cases had chronic diseases of the ENT organs (chronic tonsillitis, chronic sinusitis/sinusitis). The isolated pneumococcal isolates showed resistance to penicillins and macrolides. In risk groups for chronic respiratory diseases, vaccination with the pneumococcal conjugate vaccine (PCV-13) is recommended.

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