THE RELATIONSHIP OF ARTERIAL AND MYOCARDIAL STIFFNESS WITH LEFT VENTRICLE DIASTOLIC DYSFUNCTION IN PATIENTS WITH ARTERIAL HYPERTENSION

Objective: to study the relationship of left ventricular diastolic dysfunction (LVDD) with the degree of myocardial and arterial stiffness arterial hypertension (AH) patients. Design and method: Study included 219 patients with I-III stages of hypertension (ESC/ESH 2018) of both sexes. The average age of the patients was 55.8 ± 11.0 years, duration of AH was 55.8 ± 11.0 years. All patients were divided into two groups: 1 - patients with LVDD, n = 113 (51.6%) and 2 - without LVDD, n = 106 (48.4%). Echocardiographic assessment was performed in M-and B-modes. The systemic and regional stiffness of arterial bed was performed applanation tonometry using the SphygmoCor. The Intima-Media thickness (IMT) of common carotid artery was measured by duplex scanning. Statistical processing was carried out using the Statistica 10.0 program. Results are presented as M ± SD and Me [Q1; Q3]. Results: Initial parameters of ultrasound examination of carotid arteries showed the evidence of IMT on the left and right in patients with LVDD. Left IMT in patients with LVDD was 1.0 [0.9; 1.2] mm versus 1.0 [0.8;1.1] mm in group without LVDD (p < 0.05); right IMT was 1.0 [0.9; 1.2] mm versus 1.0 [0.8;1.1] mm, respectively (p < 0.02). Analysis of the initial parameters of central hemodynamics and vascular stiffness, revealed some features. The Barberg index was lower in group of patients with LVDD than in patients without LVDD: 142.1 ± 26.3 versus 148.5 ± 28.5, respectively (p < 0.05). Arterial stiffness was higher in the group of patients with LVDD than in group of patients without LVDD. The pulse wave velocity (PWV) in the group 1 with LVDD was 10.8 ± 2.7 m/s, and in the 2 group without LVDD - 9.9 ± 2.8 m/s (p < 0.02). A direct correlation was found for LVDD with the severity of vascular remodeling, in particular with indices of right IMT (R = 0.153, p = 0.025), with left IMT (R = 0.141, p = 0.040) and with the PWV (R = 0.169, p = 0.015). Conclusions: Our study showed an association of the severity of arterial and myocardial stiffness with LVDD.

Перевод пока недоступен