THE EFFECT OF INDOL ALKALOIDS VINCANINE AND PIROZOLINE ON RAT AORTIC SMOOTH MUSCLE CELLS Na+/Ca2+ -EXCHANGER
Mirzaeva Yu.T.1Institute of Biophysics and Biochemistry at the National University of UzbekistanUsmanov P.B.1Institute of Biophysics and Biochemistry at the National University of UzbekistanAdizov Sh2Institute of Chemistry of Plant Substances, acad. S.Yu.Yunusov AS RUz, Tashkent, Uzbekistan
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Abstract. The article studied the relaxing effect of the indole alkaloids vincanine and pyrozoline on rat aorta preparations, and also showed the participation of the Na+/Ca2+ exchanger and voltage-dependent Ca2+ channels in the system. According to the results obtained, Na+ significantly reduces aortic contractions caused by Krebs solution and ouabain, vincanine and pyrozoline. Considering that these contractions of the aorta occur in the presence of Ca2+ ions coming directly through the Na+/Ca2+ exchange system, the action of the above alkaloids is associated with the Na+/Ca2+ exchange system.
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