STUDY OF THE FEATURES OF SINGLE-NUCLEOTIDE GENETIC POLYMORPHISM IL6 (C174G) IN PURULENT DISEASES OF THE MIDDLE EAR

Abstract: The features of the uninucleated genetic polymorphism IL6 (C174G) in purulent-inflammatory diseases of the middle ear in Uzbekistan were studied. Polymorphisms of the IL6 gene (C174G) were investigated by analyzing DNA samples by PCR in real-time. The results of the study made it possible to establish among carriers of the heterozygous C/ G genotype an unexpressed tendency to increase the risk of purulent-inflammatory diseases of the middle ear of the lung course by 1.5 times (χ 2=1.1; P = 0.3) compared with the control and 2.4 times (χ2 = 3.8; P = 0.1) compared with the moderate and severe course of the disease, as well as among carriers of the mutant genotype G / G tend to increase the likely risk of the formation of purulent-inflammatory diseases of the middle ear with moderate and severe course compared with the control by 2.2 times (χ2 =1.5; P=0.3). The findings indicate a possible contribution of the polymorphic IL6 (C174G) gene to the mechanisms of increased risk of formation of purulent-inflammatory diseases of the middle ear in Uzbekistan.

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