THE INFLUENCE OF EXTRAGENITAL PATHOLOGY OF THE MOTHER ON THE PROCESSES OF FERTILITY AND THE FORMATION OF THE IMMUNE SYSTEM OF THE OFFSPRING

The influence of extra genital pathology on the reproductive function of female rats and the structural and functional development of the immune system of the offspring was researched. More pronounced violations of reproductive function were found in females with chronic toxic hepatitis (CTH) than in autoimmune enterocolitis (AIE). The appearance of prenatal mortality in females, an increase in mortality of rat pups on days 1-3 after birth, a lag in the development of offspring, in the form of a decrease in growth and weight indicators, the mass of internal organs of rat pups, were also more pronounced in the group with CTG. Deeper structural and functional changes in early postnatal ontogenesis associated with a lag in the development of the thymus, spleen, mesenteric lymph nodes and Peyer's patches before the transition of rat pups to mixed and definitive nutrition is also characteristic of the offspring of CTG females.

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