Crystal structures of sildenafil compounds with nitrate and di(citrato)zinc counterions
Akhmatkhodja N. YunuskhodjayevDoctor of Pharmaceutical Sciences, Professor of Institute of Pharmaceutical Education and Research , 46 Building, 19 Quarter, Yunusabad District, 100114 , Tashkent , UzbekistanShokhista F. IskandarovaDoctor of Pharmaceutical Sciences, Professor of Institute of Pharmaceutical Education and Research , 46 Building, 19 Quarter, Yunusabad District, 100114 , Tashkent , UzbekistanJasur B. KomilovMaster of Pharmaceutics, Institute of Pharmaceutical Education and Research , 46 Building, 19 Quarter, Yunusabad District, 100114 , Tashkent , UzbekistanVahobjon Kh. SabirovDoctor of Chemical Sciences, Professor of Tashkent State Technical University , Almalyk Branch, Ulug’bek Str., 45, 110100 , Almalyk , Uzbekistan
ABI
Аннотация
Abstract The crystal structures of sildenafil nitrate trihydrate, (HSild)NO 3 ·3H 2 O ( 1 ), and of the complex salt [Zn(HCit) 2 ]⋅(H 2 Sild) 2 ·2EtOH·6H 2 O ( 2 ) (where Sild = sildenafil, (HSild) and (H 2 Sild) are the mono and doubly charged sildenafil captions, and HCit is the triply deprotonated citric acid) have been determined by single-crystal X-ray diffraction. The compounds have been characterized by FTIR spectroscopy and the cations studied by Hirshfeld surfaces calculations. In compound 2 , the Zn atom is octahedrally coordinated by two tridentate citrate anions. Doubly charged (H 2 Sild) 2+ cations, solvate EtOH and water molecules of crystallization fill the voids of the crystal structure.
Перевод пока недоступен
Темы
Идентификаторы
Цитирования и источники
Цитирований: 0Использованных источников: 29
Показатели — AkademScholar · Скоро