Evaluation of genotypic allelic variants of IL6 and IL10 genes in the pathogenesis of gastric ulcer according to SNP-PCR detection (pilot report)

Purpose of the study. To study the prevalence and role of allelic variants of the IL6 and IL10 genes in the pathogenesis of gastric ulcer (GU) in patients of the Gastroenterological Department of the Tashkent Medical Academy (TMA).\n\nMaterial and research methods. The allelic variant (rs1800795, IL6 (C174G)) of the IL6 gene and (rs1800896, IL10 (G1082A)) IL10 were detected in patients with GU (n=55) and healthy individuals (n=88) by SNP-PCR.\n\nResults. The results obtained on the distribution features and assessment of the degree of significance of the detected differences in the frequencies of occurrence of the allele variant and genotype for the IL10 polymorphic gene (rs1800896) between GU compared with healthy ones were characterized by the absence of statistically significant differences in the carriage of the minor allele A (χ2<3.84; P>0.05), major genotype G/G (χ2<3.84; P>0.05) and heterozygous genotype G/A (χ2<3.84; P>0.05).\n\nThe obtained results on distribution features and assessment of the degree of significance of the detected differences in the frequencies of occurrence of variants of alleles and genotypes for the polymorphic IL10 gene (rs1800896) between GU compared with healthy ones were characterized by the absence of statistically significant differences between the carriage of the minor allele A (χ2<3.84; P>0.05), major genotype G/G (χ2<3.84; P>0.05) and heterozygous genotype G/A (χ2<3.84; P>0.05).\n\nConclusions: Based on the results of the study, it can be argued that the C174G (rs1800795) polymorphic loci of the IL6 gene play a significant role in the mechanisms of GU formation in Uzbekistan.

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